Clinical Insights

The Science Behind the Prevention Window

Research, analysis, and clinical perspective on menopause, cardiovascular risk, and what it means to catch it early.

Featured Framework

Understanding MERCI

MERCI, The First Cardiovascular Index Built for the Menopause Transition

Why perimenopause is the most important cardiovascular prevention window, and how the Menopause Early Risk of Cardiovascular Index tracks it. A full clinical framework, from the biology of estrogen loss to how LUCI delivers the score to your care team before every visit.

Read the Framework

Clinical Perspectives

Deeper dives into the science behind the menopause–cardiovascular risk connection.

Cardiovascular Biology

The Hormonal Cascade: How Estrogen Loss Drives Cardiovascular Risk

A clinical deep dive into the vascular, lipid, and calcium mechanisms that make perimenopause a cardiovascular event.

Hormonal Science

Estrogen's Hidden Role as a Cardiovascular Guardian

Decades of research show estrogen protects the heart in ways we are only beginning to fully understand, and what its loss means.

Prevention Strategy

Ten Years That Change Everything: The Case for Earlier Cardiovascular Intervention

The evidence for treating perimenopause as a cardiovascular prevention window, not just a reproductive transition.

Work With Us on MERCI

MERCI is in active development within LUCI and currently in early clinical review. If your practice works with perimenopausal patients and you want to be part of shaping how this framework is validated, reach out to our team.

Talk to Our Clinical Team